Description
A potent and selective FXR agonist with EC50 of 15nM in cell-free assay, >200-fold more potent than CDCA; has an EC50 of 80 and 90nM, respectively, in CV-1 cells transfected with mouse and human FXR expression vectors; significantly reducess serum alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase, as well as other markers of liver damage in rat models of cholestasis